TY  - RPRT
VL  - arXiv:1705.07850
ID  - eprints3751
N2  - Essential genes constitute the core of genes which cannot be mutated too much nor lost along the adaptive evolutionary history of a species. Natural selection is expected to be stricter on essential genes and on conserved (highly shared) genes, than on genes that are either nonessential or peculiar to a single or a few species. In order to further assess this expectation, we study here how essentiality of a gene is connected with its degree of conservation among several unrelated bacterial species, each one characterised by its own codon usage bias. Confirming previous results on E- Coli, we show the existence of a universal exponential correlation between gene essentiality and conservation in bacteria. Moreover, we show that, within each bacterial genome, there are at least two groups of functionally distinct genes, characterised by different levels of conservation and codon bias: i) a core of essential genes, mainly related to cellular information processing; ii) a set of less conserved genes with prevalent functions related to metabolism. The genes in the first group are more retained among species, are subject to a relatively purifying conservative selection and display a more selected choice of synonymous codons.The core of essential genes is close to the minimal bacterial genome, which is in the focus of recent studies in synthetic biology, though we confirm that othologues of genes that are essential in one species are not necessarily essential in other species. We also list a set of highly shared genes, which could constitute a reservoir of targets for new anti-microbial drugs.
M1  - working_paper
PB  - arXiv
A1  - Dilucca, Maddalena
A1  - Cimini, Giulio
A1  - Giansanti, Andrea
UR  - https://arxiv.org/abs/1705.07850
Y1  - 2017///
TI  - Essentiality, conservation, evolutionary pressure and codon bias in bacterial genes
AV  - public
ER  -