eprintid: 3770
rev_number: 6
eprint_status: archive
userid: 69
dir: disk0/00/00/37/70
datestamp: 2017-09-04 13:40:21
lastmod: 2017-09-04 13:40:21
status_changed: 2017-09-04 13:40:21
type: article
metadata_visibility: show
creators_name: Betta, Monica
creators_name: Laurino, Marco
creators_name: Pugliese, Andrea
creators_name: Guzzetta, Giorgio
creators_name: Landi, Alberto
creators_name: Manfredi, Piero
creators_id: monica.betta@imtlucca.it
creators_id: 
creators_id: 
creators_id: 
creators_id: 
creators_id: 
title: Perspectives on optimal control of varicella and herpes zoster by mass routine varicella vaccination
ispublished: pub
subjects: QH301
subjects: R1
divisions: CSA
full_text_status: none
abstract: Herpes zoster arises from reactivation of the varicella–zoster virus (VZV), causing varicella in children. As reactivation occurs when cell-mediated immunity (CMI) declines, and there is evidence that re-exposure to VZV boosts CMI, mass varicella immunization might increase the zoster burden, at least for some decades. Fear of this natural zoster boom is the main reason for the paralysis of varicella immunization in Europe. We apply optimal control to a realistically parametrized age-structured model for VZV transmission and reactivation to investigate whether feasible varicella immunization paths that are optimal in controlling both varicella and zoster exist. We analyse the optimality system numerically focusing on the role of the cost functional, of the relative zoster–varicella cost and of the planning horizon length. We show that optimal programmes will mostly be unfeasible for public health owing to their complex temporal profiles. This complexity is the consequence of the intrinsically antagonistic nature of varicella immunization programmes when aiming to control both varicella and zoster. However, we show that gradually increasing—hence feasible—vaccination schedules can perform better than routine programmes with constant vaccine uptake. Finally, we show the optimal profiles of feasible programmes targeting mitigation of the post-immunization natural zoster boom with priority.
date: 2016
date_type: published
publication: Proceedings of the Royal Society B: Biological Sciences
volume: 283
number: 1826
pagerange: 20160054
id_number: doi:10.1098/rspb.2016.0054
refereed: TRUE
issn: 0962-8452
official_url: http://doi.org/10.1098/rspb.2016.0054
citation:   Betta, Monica and Laurino, Marco and Pugliese, Andrea and Guzzetta, Giorgio and Landi, Alberto and Manfredi, Piero  Perspectives on optimal control of varicella and herpes zoster by mass routine varicella vaccination.  Proceedings of the Royal Society B: Biological Sciences, 283 (1826).  p. 20160054.  ISSN 0962-8452      (2016)