@inproceedings{eprints3771, publisher = {IEEE}, year = {2015}, pages = {4439--4442}, title = {Procoagulant control strategies for the human blood clotting process}, booktitle = {37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)}, author = {Marco Laurino and Tommaso Menara and Alessandro Stella and Monica Betta and Alberto Landi}, url = {http://eprints.imtlucca.it/3771/}, abstract = {This paper describes the comparison between two drug control strategies to hemophilia A. To emulate blood clotting and the pathological condition of hemophilia, a mathematical model composed by 14 ordinary differential equations is considered. We adopt a variable structure non-linear PID approach and a Model Predictive Control in order to control the dosage of procoagulant factor used in the treatment of hemophiliac patient. The two control actions are sampled for a practical application. Finally, we discuss and compare the results of the two control approaches, introducing a suited control index (eINR).} }