%D 2015
%R doi:10.1109/EMBC.2015.7319380
%I IEEE
%P 4439-4442
%T Procoagulant control strategies for the human blood clotting process
%L eprints3771
%A Marco Laurino
%A Tommaso Menara
%A Alessandro Stella
%A Monica Betta
%A Alberto Landi
%B 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)
%X This paper describes the comparison between two drug control strategies to hemophilia A. To emulate blood clotting and the pathological condition of hemophilia, a mathematical model composed by 14 ordinary differential equations is considered. We adopt a variable structure non-linear PID approach and a Model Predictive Control in order to control the dosage of procoagulant factor used in the treatment of hemophiliac patient. The two control actions are sampled for a practical application. Finally, we discuss and compare the results of the two control approaches, introducing a suited control index (eINR).
%C Milan, Italy