relation: http://eprints.imtlucca.it/3773/
title: Combining pharmacological therapy and vaccination in Chronic Myeloid Leukemia via model predictive control
creator: Laurino, Marco
creator: Stano, Maurizio
creator: Betta, Monica
creator: Pannocchia, Gabriele
creator: Landi, Alberto
subject: QH301 Biology
subject: R Medicine (General)
description: This paper describes a simulation study which aims at optimizing the therapy for the control of Chronic Myeloid Leukemia according to the following objectives: the reduction of the administered drug and vaccine amounts, the establishment of a auto-immune response and the long-term control of disease without reducing the effective of therapy with respect to the full treatment. A therapy optimization method is developed defining and solving a Model Predictive Control algorithm, preceded by an accurate Initial Guess search based on Monte-Carlo like approach. Simulation results show that the suggested procedure achieves the proposed goals.
publisher: IEEE
date: 2013
type: Conference or Workshop Item
type: PeerReviewed
identifier:   Laurino, Marco and Stano, Maurizio and Betta, Monica and Pannocchia, Gabriele and Landi, Alberto  Combining pharmacological therapy and vaccination in Chronic Myeloid Leukemia via model predictive control.  In: 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), July 3-7, 2013, Osaka, Japan pp. 3925-3928. ISSN 1558-4615. ISBN 978-1-4577-0216-7.    (In Press)   (2013)  
relation: http://doi.org/10.1109/EMBC.2013.6610403
relation: doi:10.1109/EMBC.2013.6610403