%0 Conference Paper
%A Laurino, Marco
%A Stano, Maurizio
%A Betta, Monica
%A Pannocchia, Gabriele
%A Landi, Alberto
%B 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)
%C Osaka, Japan
%D 2013
%F eprints:3773
%I IEEE
%P 3925-3928
%T Combining pharmacological therapy and vaccination in Chronic Myeloid Leukemia via model predictive control
%U http://eprints.imtlucca.it/3773/
%X This paper describes a simulation study which aims at optimizing the therapy for the control of Chronic Myeloid Leukemia according to the following objectives: the reduction of the administered drug and vaccine amounts, the establishment of a auto-immune response and the long-term control of disease without reducing the effective of therapy with respect to the full treatment. A therapy optimization method is developed defining and solving a Model Predictive Control algorithm, preceded by an accurate Initial Guess search based on Monte-Carlo like approach. Simulation results show that the suggested procedure achieves the proposed goals.