eprintid: 3773
rev_number: 6
eprint_status: archive
userid: 69
dir: disk0/00/00/37/73
datestamp: 2017-09-04 13:51:16
lastmod: 2017-09-04 13:51:16
status_changed: 2017-09-04 13:51:16
type: conference_item
metadata_visibility: show
creators_name: Laurino, Marco
creators_name: Stano, Maurizio
creators_name: Betta, Monica
creators_name: Pannocchia, Gabriele
creators_name: Landi, Alberto
creators_id: 
creators_id: 
creators_id: monica.betta@imtlucca.it
creators_id: 
creators_id: 
title: Combining pharmacological therapy and vaccination in Chronic Myeloid Leukemia via model predictive control
ispublished: inpress
subjects: QH301
subjects: R1
divisions: CSA
full_text_status: none
pres_type: paper
abstract: This paper describes a simulation study which aims at optimizing the therapy for the control of Chronic Myeloid Leukemia according to the following objectives: the reduction of the administered drug and vaccine amounts, the establishment of a auto-immune response and the long-term control of disease without reducing the effective of therapy with respect to the full treatment. A therapy optimization method is developed defining and solving a Model Predictive Control algorithm, preceded by an accurate Initial Guess search based on Monte-Carlo like approach. Simulation results show that the suggested procedure achieves the proposed goals.
date: 2013
date_type: published
publisher: IEEE
pagerange: 3925-3928
event_title: 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)
event_location: Osaka, Japan
event_dates: July 3-7, 2013
event_type: conference
id_number: doi:10.1109/EMBC.2013.6610403
refereed: TRUE
isbn: 978-1-4577-0216-7
issn: 1558-4615
book_title: 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)
official_url: http://doi.org/10.1109/EMBC.2013.6610403
citation:   Laurino, Marco and Stano, Maurizio and Betta, Monica and Pannocchia, Gabriele and Landi, Alberto  Combining pharmacological therapy and vaccination in Chronic Myeloid Leukemia via model predictive control.  In: 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), July 3-7, 2013, Osaka, Japan pp. 3925-3928. ISSN 1558-4615. ISBN 978-1-4577-0216-7.    (In Press)   (2013)