eprintid: 4076 rev_number: 13 eprint_status: archive userid: 69 dir: disk0/00/00/40/76 datestamp: 2020-04-16 09:53:42 lastmod: 2022-12-20 15:03:26 status_changed: 2020-04-16 10:06:09 type: monograph metadata_visibility: show creators_name: Paggi, Marco creators_id: marco.paggi@imtlucca.it title: Simulation of Covid-19 epidemic evolution: are compartmental models really predictive? ispublished: pub subjects: HA subjects: TJ divisions: CSA full_text_status: public monograph_type: imt_cs_techninal_report keywords: SARS-CoV-2; Covid-19; Epidemic evolution simulation abstract: Computational models for the simulation ofthe severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemic evolution would be extremely useful to support authorities in designing healthcare policies and lockdown measures to contain its impact on public health and economy. In Italy, the devised forecasts have been mostly based on a pure data-driven approach, by fitting and extrapolating open data on the epidemic evolution collected by the Italian Civil Protection Center. In this respect, SIR epidemiological models, which start from the description of the nonlinear interactions between population compartments, would be a much more desirable approach to understand and predict the collective emergent response. The present contribution addresses the fundamental question whether a SIR epidemiological model, suitably enriched with asymptomatic and dead individual compartments, could be able to provide reliable predictions on the epidemic evolution. To this aim, a machine learning approach based on particle swarm optimization (PSO) is proposed to automatically identify the model parameters based on a training set of data of progressive increasing size, considering Lombardy in Italy as a case study. The analysis of the scatter in the forecasts shows that model predictions are quite sensitive to the size of the dataset used for training, and that further data are still required to achieve convergent - and therefore reliable- predictions. date: 2020-04-16 date_type: published number: 11 publisher: IMT School for Advanced Studies Lucca place_of_pub: Lucca pages: 15 institution: IMT School for Advanced Studies Lucca referencetext: [1] John Hopkins University. Worldwide open data on Covid-19. https://github.com/CSSEGISandData/COVID-19 [2] Italian Civil Protection Center. Open data on Covid-19 in Italy. https://github.com/ondata/covid19italia [3] A. Remuzzi, G. Remuzzi. COVID-19 and Italy: what next? The Lancet Health Policy, 395:1225-1228, 2020. https://doi.org/10.1016/S0140-6736(20)30627-9 [4] G. De Nicolao. Previsione della crescita esponenziale dei Covid19-positivi in Italia, Lombardia, Veneto ed E. Romagna, 02/03/2020. https://statisticallearningtheory.wordpress.com/2020/03/02/previsione-dellacrescita-esponenziale-dei-covid19-positivi-in-italia-lombardia-veneto-ed-e-romagna/ [5] E.M. Bucci, E. Marinari. Considerazioni sull’evoluzione in corso dell’epidemia da nuovo coronavirus SARS-nCOV-2 in Italia, 2020. http://chimera.roma1.infn.it/ENZO/esponenziale.pdf?fbclid=IwAR1m6emd_E_9HYZ_Wz lzuhgZHcIkvExGhNzWecO9xsxL-hn2VxVv8odw9nk [6] A. Traficante, D. Teresi, D. Buttazzo. Coronavirus: secondo il modello matematico possibile a breve un calo dei contagi in Italia, 07/03/2020. https://www.huffingtonpost.it/entry/coronavirus-secondo-il-modello-matematicopossibile-a-breve-un-calo-dei-contagi_it_5e636b7ec5b6670e72f8999a 12 [7] M. Neri. Coronavirus, la Toscana aspetta il picco di casi: ecco le due previsioni (ottimistica e pessimistica), 17/03/2020. https://m.ilgiornale.it/news/cronache/lottacontro-coronavirus-i-posti-terapia-intensiva-regione-1841903.html [8] F. Costa. I dati ufficiali non avevano senso prima e non hanno senso adesso, 12/04/2020. https://www.francescocosta.net/2020/04/12/dati-ufficiali-senza-senso [9] R. Li et al. Substantial undocumented infection facilitates the rapid dissemination of novel coronavirus (SARS-CoV2), Science, 2020. https://doi.org/10.1126/science.abb3221 [10] K. Yin Leung, P. Trapman, T. Britton. Who is the infector? Epidemic models with symptomatic and asymptomatic cases. Mathematical Biosciences, 301:190-198, 2018. https://doi.org/10.1016/j.mbs.2018.04.002 [11] G. Gaeta. A simple SIR model with a large set of asymptomatic infectives. https://arxiv.org/abs/2003.08720v1 [12] W.O. Kermack, A.G. McKendrick. Contributions to the mathematical theory of epidemics. Proc. R. Soc. Lond. A, 138: 55-83 (1932); Proc. R. Soc. Lond. A, 141:94-122 (1933). [13] D. Wang, D. Tan, L. Liu. Particle swarm optimization algorithm: an overview. Soft Computing, 22: 387-408, 2018. https://doi.org/10.1007/s00500-016-2474-6 citation: Paggi, Marco Simulation of Covid-19 epidemic evolution: are compartmental models really predictive? CSA Technical Report #11/2020 IMT School for Advanced Studies Lucca , Lucca. document_url: http://eprints.imtlucca.it/4076/1/TR_11_2020_Paggi.pdf