?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.relation=http%3A%2F%2Feprints.imtlucca.it%2F4088%2F&rft.title=Annuity+and+Conditional+Payment+Schemes+for+the+Reimbursement+of+One-Shot+Advanced+Therapies&rft.creator=Nutarelli%2C+Federico&rft.creator=Riccaboni%2C+Massimo&rft.subject=HB+Economic+Theory&rft.subject=HG+Finance&rft.description=Advanced+therapies+represent+a+paradigm+shift.+They+offer+potentially+curative+solutions+to+life-threatening+diseases+through+a+single+administration.+However%2C+this+paradigm+shift+poses+unprecedented+challenges+to+the+current+model+of+drug+access+and+reimbursement+developed+for+the+management+of+conventional+therapies%2C+where+reimbursement+typically+occurs+at+the+time+of+therapy+administration.+In+this+paper%2C+we+identify+the+key+determinants+of+the+paradigm+shift+and+propose+a+new+reimbursement+model+for+advanced+therapies.+The+proposed+model+relies+on+managed+entry+agreements+to+address+payer+uncertainty+and+is+based+on+conditional+and+deferred+payments.+The+potential+impact+of+such+deferred+payments+on+spending+is+estimated+through+horizon+scanning.+Finally%2C+we+propose+the+establishment+of+a+dedicated+fund+to+enable+timely+access+to+advanced+therapies+while+ensuring+the+sustainability+of+the+impact+on+pharmaceutical+expenditure.&rft.publisher=IMT+Institute+for+Advanced+Studies+Lucca&rft.date=2025&rft.type=Working+Paper&rft.type=NonPeerReviewed&rft.format=application%2Fpdf&rft.language=en&rft.rights=cc_by_nd&rft.identifier=http%3A%2F%2Feprints.imtlucca.it%2F4088%2F1%2FWP_1_2025_corretto.pdf&rft.identifier=++Nutarelli%2C+Federico+and+Riccaboni%2C+Massimo++Annuity+and+Conditional+Payment+Schemes+for+the+Reimbursement+of+One-Shot+Advanced+Therapies.++EIC+working+paper+series+++IMT+Institute+for+Advanced+Studies+Lucca+%2C+Lucca.++++++++