eprintid: 4088
rev_number: 10
eprint_status: archive
userid: 69
dir: disk0/00/00/40/88
datestamp: 2025-04-03 08:36:33
lastmod: 2025-04-09 07:30:30
status_changed: 2025-04-03 08:36:33
type: monograph
metadata_visibility: show
creators_name: Nutarelli, Federico
creators_name: Riccaboni, Massimo
creators_id: federico.nutarelli@imtlucca.it
creators_id: massimo.riccaboni@imtlucca.it
title: Annuity and Conditional Payment Schemes for the Reimbursement of One-Shot Advanced Therapies
ispublished: pub
subjects: HB
subjects: HG
divisions: EIC
full_text_status: public
monograph_type: imt_eic_working_paper
abstract: Advanced therapies represent a paradigm shift. They offer potentially curative solutions to life-threatening diseases through a single administration. However, this paradigm shift poses unprecedented challenges to the current model of drug access and reimbursement developed for the management of conventional therapies, where reimbursement typically occurs at the time of therapy administration. In this paper, we identify the key determinants of the paradigm shift and propose a new reimbursement model for advanced therapies. The proposed model relies on managed entry agreements to address payer uncertainty and is based on conditional and deferred payments. The potential impact of such deferred payments on spending is estimated through horizon scanning. Finally, we propose the establishment of a dedicated fund to enable timely access to advanced therapies while ensuring the sustainability of the impact on pharmaceutical expenditure.
date: 2025
date_type: published
publisher: IMT Institute for Advanced Studies Lucca
place_of_pub: Lucca
institution: IMT Institute for Advanced Studies Lucca
citation:   Nutarelli, Federico and Riccaboni, Massimo  Annuity and Conditional Payment Schemes for the Reimbursement of One-Shot Advanced Therapies.  EIC working paper series   IMT Institute for Advanced Studies Lucca , Lucca.        
document_url: http://eprints.imtlucca.it/4088/1/WP_1_2025_corretto.pdf