TY - JOUR KW - Simulation-optimization; Uncertainty; Robustness; Metamodel; Bootstrap VL - 2 UR - http://www.sciencedirect.com/science/article/pii/S1877042810012978 A1 - Dellino, Gabriella A1 - Kleijnen, Jack P.C. A1 - Meloni, Carlo Y1 - 2010/// TI - Simulation-optimization under uncertainty through metamodeling and bootstrapping SP - 7640 N1 - Sixth International Conference on Sensitivity Analysis of Model Output AV - none IS - 6 PB - Elsevier JF - Procedia - Social and Behavioral Sciences N2 - Most methods in simulation-optimization assume known environments, whereas this research accounts for uncertain environments combining Taguchi's world view with either regression or Kriging (Gaussian Process) metamodels (response surfaces). These metamodels are combined with Non-Linear Mathematical Programming (NLMP) to find a robust optimal solution. Varying the constraint values in the NLMP model gives an estimated Pareto frontier. To account for the variability of the estimated Pareto frontier, this research uses bootstrapping which gives confidence regions for the robust optimal solution. This methodology is illustrated through the Economic Order Quantity (EOQ) inventory-management model, accounting for the uncertainties in the demand rate and the cost coefficients. ID - eprints754 EP - 7641 SN - 1877-0428 ER -