eprintid: 797
rev_number: 21
eprint_status: archive
userid: 35
dir: disk0/00/00/07/97
datestamp: 2011-08-11 10:23:31
lastmod: 2013-03-05 15:40:36
status_changed: 2011-08-11 10:23:31
type: article
metadata_visibility: show
item_issues_count: 0
creators_name: Dharmakumar, Rohan
creators_name: Zhang, Zheng 
creators_name: Koktzoglou, Ioannis
creators_name: Tsaftaris, Sotirios A.
creators_name: Li, Debiao
creators_id: 
creators_id: 
creators_id: 
creators_id: sotirios.tsaftaris@imtlucca.it
creators_id: 
title: Dual-contrast cellular magnetic resonance imaging
ispublished: pub
subjects: QA76
subjects: QC
subjects: RC
divisions: CSA
full_text_status: none
abstract: Negative contrast magnetic resonance imaging (MRI) methods using magnetic susceptibility shifting agents have become one of the most important approaches in cellular imaging research. However, visualizing and tracking labeled cells on the basis of negative contrast is often met with limited specificity and sensitivity. Here we report on a MRI method for cellular imaging that generates a new contrast with a distinct topology for identifying labeled cells that has the potential to significantly improve both the sensitivity and the specificity. Specifically, we show that low flip-angle steady-state free precession MRI can be used to generate fast three-dimensional images of tissue that can be rapidly processed to generate quantitative metrics enabling color overlays indicative of regions containing labeled cells. The technique substantially improves the ability of MRI for detecting labeled cells by overcoming the fundamental limits that currently plague negative contrast methods.
date: 2009-09
date_type: published
publication: Molecular imaging
volume: 8
number: 5
publisher: BC Decker
pagerange: 254-263
refereed: TRUE
issn: 1535-3508
official_url: http://www.bcdecker.com/pubMedLinkOut.aspx?pub=MIO&vol=8&iss=5&page=254
citation:   Dharmakumar, Rohan and Zhang, Zheng  and Koktzoglou, Ioannis and Tsaftaris, Sotirios A. and Li, Debiao  Dual-contrast cellular magnetic resonance imaging.  Molecular imaging, 8 (5).  pp. 254-263.  ISSN 1535-3508      (2009)