eprintid: 846 rev_number: 21 eprint_status: archive userid: 35 dir: disk0/00/00/08/46 datestamp: 2011-09-08 13:04:29 lastmod: 2013-03-05 15:34:48 status_changed: 2011-09-08 13:04:29 type: conference_item metadata_visibility: no_search item_issues_count: 0 creators_name: Dharmakumar, Rohan creators_name: Zhang, Zheng creators_name: Koktzoglou, Ioannis creators_name: Tsaftaris, Sotirios A. creators_name: Li, Debiao creators_id: creators_id: creators_id: creators_id: sotirios.tsaftaris@imtlucca.it creators_id: title: Dual contrast cellular MRI ispublished: unpub subjects: QA76 subjects: RC subjects: TK divisions: CSA full_text_status: none pres_type: poster abstract: Negative contrast MRI methods utilizing local magnetic susceptibility shifting (LMS) agents have become an active area of cellular imaging research. However, visualizing and tracking labeled cells on the basis of negative contrast is often plagued by limited specificity and/or sensitivity. Here we report on a cellular MRI method that generates a new contrast with a distinct topology for identifying labeled cells permitting significant improvement in sensitivity and specificity. Specifically, we show that FLAPS MRI [1],MRI can be used to generate fast three-dimensional images of tissue that can be rapidly processed to generate quantitative metrics enabling color overlays indicative of regions containing labeled cells. date: 2010 event_title: 18th Meeting of the international society for magnetic resonance in medicine event_location: Stockholm, Sweden event_dates: 1-7 May 2010 event_type: conference refereed: TRUE official_url: http://eta2.bio.cmu.edu/ISMRM/ISMRM%202010%20Stockholm/files/4188_6096.pdf citation: Dharmakumar, Rohan and Zhang, Zheng and Koktzoglou, Ioannis and Tsaftaris, Sotirios A. and Li, Debiao Dual contrast cellular MRI. In: 18th Meeting of the international society for magnetic resonance in medicine, 1-7 May 2010, Stockholm, Sweden (Unpublished) (2010)