relation: http://eprints.imtlucca.it/852/
title: An area-based imaging biomarker for the characterization of coronary artery stenosis with blood oxygen-sensitive MRI
creator: Tsaftaris, Sotirios A.
creator: Tang, Richard
creator: Zhou, Xiangzhi 
creator: Li, Debiao
creator: Dharmakumar, Rohan
subject: RC Internal medicine
subject: TK Electrical engineering. Electronics Nuclear engineering
description: BOLD MRI may be used for detecting myocardial oxygenation changes secondary to coronary artery stenosis (1-3). Under  pharmacological stress, the myocardial bed supplied by the stenotic coronary artery appears hypointense relative to healthy regions in BOLD images. Manual windowing (to visualize signal changes) and segmentation according to the American Heart Association’s (AHA) recommendation are often used to characterize the BOLD effect. However, current approaches for analyzing BOLD changes are suboptimal for detecting critical stenosis (reduction in perfusion reserve below 2:1). The purpose of this study is to test the hypothesis that, ARREAS (Area-based biomaRker for chaRactErizing coronAry Stenosis), an area-based statistical approach relying on the differences between rest and stress images, can characterize BOLD changes in end-systole and end-diastole with exquisite sensitivity and specificity. This hypothesis was tested in a canine model.
date: 2011
type: Conference or Workshop Item
type: PeerReviewed
identifier:   Tsaftaris, Sotirios A. and Tang, Richard and Zhou, Xiangzhi  and Li, Debiao and Dharmakumar, Rohan  An area-based imaging biomarker for the characterization of coronary artery stenosis with blood oxygen-sensitive MRI.  In: 19th meeting of the international society for magnetic resonance in medicine, 7-13 May 2011, Montreal, Quebec, Canada       (Unpublished)   (2011)  
relation: http://submissions.miracd.com/ismrm2011/proceedings/files/1344.pdf