eprintid: 852
rev_number: 17
eprint_status: archive
userid: 35
dir: disk0/00/00/08/52
datestamp: 2011-09-09 12:28:14
lastmod: 2013-03-05 15:30:15
status_changed: 2011-09-09 12:28:14
type: conference_item
metadata_visibility: show
item_issues_count: 0
creators_name: Tsaftaris, Sotirios A.
creators_name: Tang, Richard
creators_name: Zhou, Xiangzhi 
creators_name: Li, Debiao
creators_name: Dharmakumar, Rohan
creators_id: sotirios.tsaftaris@imtlucca.it
creators_id: 
creators_id: 
creators_id: 
creators_id: 
title: An area-based imaging biomarker for the characterization of coronary artery stenosis with blood oxygen-sensitive MRI
ispublished: unpub
subjects: RC
subjects: TK
divisions: CSA
full_text_status: none
pres_type: poster
abstract: BOLD MRI may be used for detecting myocardial oxygenation changes secondary to coronary artery stenosis (1-3). Under
pharmacological stress, the myocardial bed supplied by the stenotic coronary artery appears hypointense relative to healthy regions in BOLD images. Manual windowing (to visualize signal changes) and segmentation according to the American Heart Association’s (AHA) recommendation are often used to characterize the BOLD effect. However, current approaches for analyzing BOLD changes are suboptimal for detecting critical stenosis (reduction in perfusion reserve below 2:1). The purpose of this study is to test the hypothesis that, ARREAS (Area-based biomaRker for chaRactErizing coronAry Stenosis), an area-based statistical approach relying on the differences between rest and stress images, can characterize BOLD changes in end-systole and end-diastole with exquisite sensitivity and specificity. This hypothesis was tested in a canine model.
date: 2011
event_title: 19th meeting of the international society for magnetic resonance in medicine
event_location: Montreal, Quebec, Canada
event_dates: 7-13 May 2011
event_type: conference
refereed: TRUE
official_url: http://submissions.miracd.com/ismrm2011/proceedings/files/1344.pdf
citation:   Tsaftaris, Sotirios A. and Tang, Richard and Zhou, Xiangzhi  and Li, Debiao and Dharmakumar, Rohan  An area-based imaging biomarker for the characterization of coronary artery stenosis with blood oxygen-sensitive MRI.  In: 19th meeting of the international society for magnetic resonance in medicine, 7-13 May 2011, Montreal, Quebec, Canada       (Unpublished)   (2011)