IMT Institutional Repository: No conditions. Results ordered -Date Deposited. 2024-03-28T14:41:41ZEPrintshttp://eprints.imtlucca.it/images/logowhite.pnghttp://eprints.imtlucca.it/2015-11-10T11:47:36Z2016-09-13T09:46:12Zhttp://eprints.imtlucca.it/id/eprint/2873This item is in the repository with the URL: http://eprints.imtlucca.it/id/eprint/28732015-11-10T11:47:36ZMorphometric Changes of the Corpus Callosum in Congenital BlindnessWe examined the effects of visual deprivation at birth on the development of the corpus callosum in a large group of congenitally blind individuals. We acquired high-resolution T1-weighted MRI scans in 28 congenitally blind and 28 normal sighted subjects matched for age and gender. There was no overall group effect of visual deprivation on the total surface area of the corpus callosum. However, subdividing the corpus callosum into five subdivisions revealed significant regional changes in its three most posterior parts. Compared to the sighted controls, congenitally blind individuals showed a 12 reduction in the splenium, and a 20 increase in the isthmus and the posterior part of the body. A shape analysis further revealed that the bending angle of the corpus callosum was more convex in congenitally blind compared to the sighted control subjects. The observed morphometric changes in the corpus callosum are in line with the well-described cross-modal functional and structural neuroplastic changes in congenital blindness.Francesco TomaiuoloSerena CampanaD. Louis CollinsVladimir S. FonovEmiliano Ricciardiemiliano.ricciardi@imtlucca.itGiuseppe SartoriPietro Pietrinipietro.pietrini@imtlucca.itRon KupersMaurice Ptito