Tsaftaris, Sotirios A. and Zhou, Xiangzhi and Tang, Richard and Li, Debiao and Dharmakumar, Rohan Detecting Myocardial Ischemia at Rest with Cardiac Phase-Resolved BOLD CMR. Circulation: Cardiovascular Imaging. ISSN 1941-9651 (2012)Full text not available from this repository.
Background—Fast, noninvasive identification of ischemic territories at rest (prior to tissue-specific changes) and assessment of functional status can be valuable in the management of severe coronary artery disease. This study investigated the utility of cardiac phase-resolved Blood-Oxygen-Level-Dependent (CP-BOLD) CMR in detecting myocardial ischemia at rest secondary to severe coronary artery stenosis. Methods and Results—CP-BOLD, standard-cine, and T2-weighted images were acquired in canines (n=11) at baseline and within 20 minutes of ischemia induction (severe LAD stenosis) at rest. Following 3-hours of ischemia, LAD stenosis was removed and T2-weighted and late-gadolinium-enhancement (LGE) images were acquired. From standard-cine and CP-BOLD images, End-Systolic (ES) and End-Diastolic (ED) myocardium were segmented. Affected and remote sections of the myocardium were identified from post-reperfusion LGE images. S/D, quotient of mean ES and ED signal intensities (on CP-BOLD and standard-cine), was computed for affected and remote segments at baseline and ischemia. Ejection fraction (EF) and segmental wall-thickening (sWT) were derived from CP-BOLD images at baseline and ischemia. On CP-BOLD images: S/D was greater than 1 (remote and affected territories) at baseline; S/D was diminished only in affected territories during ischemia and the findings were statistically significant (ANOVA, post-hoc p<0.01). The dependence of S/D on ischemia was not observed in standard-cine images. Computer simulations confirmed the experimental findings. ROC analysis showed that S/D identifies affected regions with similar performance (AUC:0.87) as EF (AUC:0.89) and sWT (AUC:0.75). Conclusions—Preclinical studies and computer simulations showed that CP-BOLD CMR could be useful in detecting myocardial ischemia at rest. Patient studies are needed for clinical translation.
|Additional Information:||Published online before print December 18, 2012.|
|Uncontrolled Keywords:||acute coronary syndrome; coronary artery disease; ischemia; BOLD; MRI|
|Subjects:||Q Science > QA Mathematics > QA75 Electronic computers. Computer science
R Medicine > RC Internal medicine
|Research Area:||Computer Science and Applications|
|Depositing User:||Users 35 not found.|
|Date Deposited:||05 Mar 2013 14:57|
|Last Modified:||12 Mar 2013 09:32|
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