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Emotional dysregulation in social anxiety insights from an fMRI resting-state study

Gentili, Claudio and Vanello, Nicola and Cristea, Ioana and Ricciardi, Emiliano and David, Daniel and Pietrini, Pietro and Guazzelli, Mario Emotional dysregulation in social anxiety insights from an fMRI resting-state study. International Journal of Psychophysiology, 85 (3). p. 339. ISSN 0167-8760 (2012)

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The relationship between Social Phobia (SP) and subclinical social anxiety (SA), as well as with normal shyness is not completely defined. We used the Hurst Exponent (HE) to test the hypothesis that, even in a not socially anxious condition, relevant regions for the neurobiology of SP will display a relation between Social Anxiety levels as measured by psychological scales and HE of the BOLD signal. Resting-state fMRI time series were recorded in 26 subjects (12 F; mean age ± SD. = 26 ± 3). All the subjects were drug free and did notrefer any psychiatric disorder in the anamnesis. Each subject completed the following scales: Brief Fear of Negative Evaluation (BFNE), Interaction Anxiousness Scale (IAS), Liebowitz Social Anxiety scale (LSAS), Social Anxiety Spectrum Self-Report (SHI-SR) and State-Trait Anxiety Scale. The Hurst exponent was estimated by using the discrete second-order derivative approach and its relationship with SA has been tested in the whole brain and in regions known to be involved in SP. LSAS score predicted the HE in the anterior cingulate cortex (ACC), amygdala, cerebellum (all negatively) and precuneus (positively). ROI analysis showed an inverse correlation between LSAS and SHI-SR scores and HE in the amygdala and a direct correlation between IAS and BFNE scores in the precuneus. Our results suggest that the brain pattern of spontaneous activity is influenced by the degree of SA on a continuum in relevant regions for reappraisal and emotional regulation. We discuss our results in the framework of available knowledge on SA including the Clark ]";and Wells (1995) model of SA and the etiologic theories on emotional dysregulation in SA.

Item Type: Article
Identification Number: 10.1016/j.ijpsycho.2012.06.132
Additional Information: Proceedings of the 16th World Congress of Psycophysiology of the International Organization of Psychophysiology (IOP) Pisa, Italy September 13-17, 2012
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Research Area: Computer Science and Applications
Depositing User: Caterina Tangheroni
Date Deposited: 10 Nov 2015 13:02
Last Modified: 13 Sep 2016 09:50
URI: http://eprints.imtlucca.it/id/eprint/2879

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