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Reconstruction of DSC-MRI Data from Sparse Data Exploiting Temporal Redundancy and Contrast Localization

Boschetto, Davide and Castellaro, M. and Di Prima, P. and Bertoldo, A. and Grisan, Enrico Reconstruction of DSC-MRI Data from Sparse Data Exploiting Temporal Redundancy and Contrast Localization. In: XIII Mediterranean Conference on Medical and Biological Engineering and Computing 2013. IFMBE Proceedings, 41 . Springer International Publishing, pp. 225-228. ISBN 978-3-319-00845-5 (2014)

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In order to asses brain perfusion, one of the available methods is the estimation of parameters such as cerebral blood flow (CBF), cerebral blood volume (CBV) and mean transit time (MTT) from Dynamic Susceptibility Contrast-MRI (DSC-MRI). This estimation requires both high temporal resolution to capture the rapid tracer kinetic, and high spatial resolution to detect small impairments and reliably discriminate boundaries.With this inmind, we propose a compressed sensing approach to decrease the acquisition time without sacrificing the reconstruction, especially in the region affected by tracer passage. To this end we propose the utilization of an available TVL1- L2 minimization scheme with a novel additional term that introduce the information on the volume at baseline (no tracer). We show on simulated data the benefit of such a scheme, that is able to achieve an accurate reconstruction even at high acceleration (x16), with a RMSE of 2.8, 10 times lower than the error obtained with the original reconstruction.

Item Type: Book Section
Identification Number: 10.1007/978-3-319-00846-2_56
Uncontrolled Keywords: Compressed sensing, MRI, Dynamic susceptibility, DSC-MRI, Contrast kinetics
Subjects: Q Science > QA Mathematics > QA75 Electronic computers. Computer science
T Technology > T Technology (General)
Research Area: Computer Science and Applications
Depositing User: Caterina Tangheroni
Date Deposited: 20 Jan 2016 10:15
Last Modified: 06 Apr 2016 07:35
URI: http://eprints.imtlucca.it/id/eprint/3024

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