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Deficiency and supplementation of {PUFA} in the diet have similar effects on the age-associated changes in rat-plasma cholesterol levels

Straniero, Sara and Cavallini, Gabriella and Donati, Alessio and Metelli, Maria Rita and Tamburini, Ilaria and Pietrini, Pietro and Bergamini, Ettore Deficiency and supplementation of {PUFA} in the diet have similar effects on the age-associated changes in rat-plasma cholesterol levels. Mechanisms of Ageing and Development, 129 (12). 759 - 762. ISSN 0047-6374 (2008)

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Abstract

Levels of plasma cholesterol, particularly {LDL} cholesterol, increase with increasing age in humans and rodents. Feeding a fish oil-rich diet may exert hypocholesterolemic effects. The aim of this work was to examine the effects of a life-long administration of a PUFA-enriched diet and of a PUFA-deficient diet in male Sprague–Dawley rats on the age-associated increases in plasma cholesterol and triglycerides. Diet had small effects on body-weight, and had dramatic effects on liver phospholipids-fatty acids. Surprisingly, both diets counteracted the age-associated changes in plasma cholesterol and triglycerides similarly and benefits were already visible in adult rats.

Item Type: Article
Identification Number: https://doi.org/10.1016/j.mad.2008.09.009
Uncontrolled Keywords: Ageing; Cholesterol; Triglycerides; Dietary PUFA; Rat
Subjects: Q Science > QH Natural history > QH301 Biology
Q Science > QP Physiology
Research Area: Computer Science and Applications
Depositing User: Caterina Tangheroni
Date Deposited: 19 Feb 2016 12:45
Last Modified: 19 Feb 2016 12:45
URI: http://eprints.imtlucca.it/id/eprint/3091

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