Huey, Edward D. and Grafman, Jordan and Wassermann, Eric M. and Pietrini, Pietro and Tierney, Michael C. and Ghetti, Bernardino and Spina, Salvatore and Baker, Matt and Hutton, Mike and Elder, Joshua W. and Berger, Stephen L. and Heflin, Kyle A. and Hardy, John and Momeni, Parastoo Characteristics of frontotemporal dementia patients with a Progranulin mutation. Annals of Neurology, 60 (3). pp. 374-380. ISSN 0364-5134 (2006)
Full text not available from this repository.Abstract
ObjectiveMutations in the Progranulin gene (PGRN) recently have been discovered to be associated with frontotemporal dementia (FTD) linked to 17q21 without identified MAPT mutations. The range of mutations of PGRN that can result in the FTD phenotype and the clinical presentation of patients with PGRN mutations have yet to be determined.MethodsIn this study, we examined 84 FTD patients from families not known previously to have illness linked to chromosome 17 for identified PGRN and MAPT mutations and sequenced the coding exons and the flanking intronic regions of PGRN. We compared the prevalence, clinical characteristics, magnetic resonance imaging and 18-fluoro-deoxyglucose positron emission tomography results, and neuropsychological testing of patients with the PGRN R493X mutation with those patients without identified PGRN mutations.ResultsWe discovered a new PGRN mutation (R493X) resulting in a stop codon in two patients. This was the only PGRN mutation identified in our sample. The patients with the PGRN R493X mutation had a rapid illness course and had predominant right-sided atrophy and hypometabolism on magnetic resonance imaging and 18-fluoro-deoxyglucose positron emission tomography. The affected father of one of the patients with the PGRN R493X mutation showed frontal and temporal atrophy without neurofibrillary tangles on neuropathological examination.InterpretationKnown PGRN and MAPT mutations were rare and of similar prevalence in our sample (2 compared with 1/84). The patients with the PGRN R493X mutation had a clinical presentation comparable with other behavior-predominant FTD patients. The neuropathology of an affected family member of a patient with the PGRN R493X mutation appears not to be Alzheimer's disease.
| Item Type: | Article |
|---|---|
| Identification Number: | 10.1002/ana.20969 |
| Subjects: | R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry |
| Research Area: | Computer Science and Applications |
| Depositing User: | Users 72 not found. |
| Date Deposited: | 26 Feb 2016 09:51 |
| Last Modified: | 26 Feb 2016 09:51 |
| URI: | http://eprints.imtlucca.it/id/eprint/3118 |
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