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The Effect of Visual Experience on the Development of Functional Architecture in hMT+

Ricciardi, Emiliano and Vanello, Nicola and Sani, Lorenzo and Gentili, Claudio and Scilingo, Enzo Pasquale and Landini, Luigi and Guazzelli, Mario and Bicchi, Antonio and Haxby, James V. and Pietrini, Pietro The Effect of Visual Experience on the Development of Functional Architecture in hMT+. Cerebral Cortex, 17 (12). pp. 2933-2939. ISSN 1047-3211 (2007)

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We investigated whether the visual hMT+ cortex plays a role in supramodal representation of sensory flow, not mediated by visual mental imagery. We used functional magnetic resonance imaging to measure neural activity in sighted and congenitally blind individuals during passive perception of optic and tactile flows. Visual motion–responsive cortex, including hMT+, was identified in the lateral occipital and inferior temporal cortices of the sighted subjects by response to optic flow. Tactile flow perception in sighted subjects activated the more anterior part of these cortical regions but deactivated the more posterior part. By contrast, perception of tactile flow in blind subjects activated the full extent, including the more posterior part. These results demonstrate that activation of hMT+ and surrounding cortex by tactile flow is not mediated by visual mental imagery and that the functional organization of hMT+ can develop to subserve tactile flow perception in the absence of any visual experience. Moreover, visual experience leads to a segregation of the motion-responsive occipitotemporal cortex into an anterior subregion involved in the representation of both optic and tactile flows and a posterior subregion that processes optic flow only.

Item Type: Article
Identification Number: 10.1093/cercor/bhm018
Uncontrolled Keywords: Blind subjects; Functional magnetic resonance imaging (fMRI); hMT+; Optic flow; Supramodality; Tactile flow.
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Research Area: Computer Science and Applications
Depositing User: Caterina Tangheroni
Date Deposited: 29 Feb 2016 10:11
Last Modified: 13 Sep 2016 10:09
URI: http://eprints.imtlucca.it/id/eprint/3162

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