Logo eprints

A poly(ether-ester) copolymer for the preparation of nanocarriers with improved degradation and drug delivery kinetics

Gagliardi, Mariacristina and Bertero, Alice and Bardi, Giuseppe and Bifone, Angelo A poly(ether-ester) copolymer for the preparation of nanocarriers with improved degradation and drug delivery kinetics. Materials Science and Engineering: C, 59. 488 - 499. ISSN 0928-4931 (2016)

Full text not available from this repository.


Abstract This paper reports the synthesis and the physicochemical, functional and biological characterisations of nanocarriers made of a novel di-block biodegradable poly(ether-ester) copolymer. This material presents tunable, fast biodegradation rates, but its products are less acidic than those of other biosorbable polymers like PLGA, thus presenting a better biocompatibility profile and the possibility to carry pH-sensitive payloads. A method for the production of monodisperse and spherical nanoparticles is proposed; drug delivery kinetics and blood protein adsorption were measured to evaluate the functional properties of these nanoparticles as drug carriers. The copolymer was labelled with a fluorescent dye for internalisation tests, and rhodamine B was used as a model cargo to study transport and release inside cultured cells. Biological tests demonstrated good cytocompatibility, significant cell internalisation and the possibility to vehiculate non-cell penetrating moieties into endothelial cells. Taken together, these results support the potential use of this nanoparticulate system for systemic administration of drugs.

Item Type: Article
Identification Number: 10.1016/j.msec.2015.10.054
Uncontrolled Keywords: Biodegradable nanoparticles; Drug delivery; Biodegradation; Biocompatibility; Metoxy polyethyleneglycol-block-poly(ε-caprolactone-co-4-hydroxyvalerolactone)
Subjects: Q Science > QD Chemistry
T Technology > TA Engineering (General). Civil engineering (General)
T Technology > TP Chemical technology
Research Area: Computer Science and Applications
Depositing User: Caterina Tangheroni
Date Deposited: 21 Mar 2016 09:02
Last Modified: 21 Mar 2016 09:19
URI: http://eprints.imtlucca.it/id/eprint/3243

Actions (login required)

Edit Item Edit Item