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Biomedical Nanoparticles: Overview of Their Surface Immune-Compatibility

Gamucci, Olimpia and Bertero, Alice and Gagliardi, Mariacristina and Bardi, Giuseppe Biomedical Nanoparticles: Overview of Their Surface Immune-Compatibility. Coatings, 4 (1). p. 139. ISSN 2079-6412 (2014)

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Diagnostic- and therapeutic release-aimed nanoparticles require the highest degree of biocompatibility. Some physical and chemical characteristics of such nanomaterials are often at odds with this requirement. For instance, metals with specific features used as contrast agents in magnetic resonance imaging need particular coatings to improve their blood solubility and increase their biocompatibility. Other examples come from the development of nanocarriers exploiting the different characteristics of two or more materials, i.e., the ability to encapsulate a certain drug by one core-material and the targeting capability of a different coating surface. Furthermore, all these “human-non-self” modifications necessitate proofs of compatibility with the immune system to avoid inflammatory reactions and resultant adverse effects for the patient. In the present review we discuss the molecular interactions and responses of the immune system to the principal nanoparticle surface modifications used in nanomedicine.

Item Type: Article
Identification Number: 10.3390/coatings4010139
Uncontrolled Keywords: Immune system; Nanomaterials; Immunogenicity; Immunotoxicity; Biodistribution; Mononuclear phagocytic cells; Surface modifications
Subjects: Q Science > QD Chemistry
R Medicine > RS Pharmacy and materia medica
Research Area: Computer Science and Applications
Depositing User: Caterina Tangheroni
Date Deposited: 21 Mar 2016 09:32
Last Modified: 21 Mar 2016 09:32
URI: http://eprints.imtlucca.it/id/eprint/3249

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