Guerra, Giulio D. and Gagliardi, Mariacristina and Barbani, Niccoletta and Cristallini, Caterina Controlled Release of the Anti-cancer Drug Paclitaxel from Bioresorbable Poly(ester-ether-ester) Microspheres. In: Recent Researches in Modern Medicine. WSEAS, pp. 210-217. ISBN 9789604742783 (2011)
Full text not available from this repository.Abstract
The release of the anti-cancer drug paclitaxel (PTX) from microspheres of the bioresorbable poly(ε-caprolactoneoxyethylene-ε-caprolactone)tri-block copolymer was studied. The microspheres, both loaded and not with PTX, were prepared by emulsion-evaporation technique, then characterized by SEM, AFM, total reflection and spotlight FT-IR spectroscopy, and DSC. The quantities of PTX released were measured by HPLC. The results showed a slow and very regular release, which fits very well the Peppas equation, Mt/M∞ = k · t, where Mt is the amount of solute released at the time t, M∞ is the amount of drug released at the plateau condition, k represents the Peppas kinetic constant and n the diffusion order.
| Item Type: | Book Section |
|---|---|
| Subjects: | Q Science > QD Chemistry R Medicine > RZ Other systems of medicine |
| Research Area: | Computer Science and Applications |
| Depositing User: | Caterina Tangheroni |
| Date Deposited: | 21 Mar 2016 10:45 |
| Last Modified: | 06 Apr 2016 07:44 |
| URI: | http://eprints.imtlucca.it/id/eprint/3257 |
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