Logo eprints

Combined drug release from biodegradable bilayer coating for endovascular stents

Gagliardi, Mariacristina and Silvestri, Davide and Cristallini, Caterina and Guadagni, M. and Crifaci, G. and Giusti, Paolo Combined drug release from biodegradable bilayer coating for endovascular stents. Journal of Biomedical Materials Research Part B: Applied Biomaterials, 93B (2). pp. 375-385. ISSN 1552-4973 (2010)

Full text not available from this repository.


In this work, the characterization of a biodegradable bilayer system, used as controlled and combined drug delivery platform, is reported. For this aim, a bilayer system, composed of poly(lactic-co-glycolic acid) and poly(3-hydroxybutyric-co-3-hydroxyvaleric acid), was investigated under physicochemical and functional aspects by evaluating polymer/polymer and polymer/stent material interactions, the kinetic of in vitro degradation, and drug release properties, comparing results with the monolayer reference systems. Obtained results showed that the bilayer system allowed increasing the total amount of eluted Tacrolimus and Paclitaxel drugs with respect to the monolayer systems in the considered testing period and conditions. This evidence was associated to a faster degradation of the tested copolymers in the bilayered configuration, excluding a synergic effect of two drugs on delivery performance. In addition, a macromolecular relaxation process was identified to govern the PLX release from poly(lactic-co-glycolic acid), whereas a pure Fickian diffusion occurred in the delivery of Tacrolimus from poly(3-hydroxybutyric-co-3-hydroxyvaleric acid). © 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2010

Item Type: Article
Identification Number: 10.1002/jbm.b.31592
Uncontrolled Keywords: Biodegradation; Coating(s); Controlled release; Vascular stents; Combined drug delivery
Subjects: Q Science > QD Chemistry
Research Area: Computer Science and Applications
Depositing User: Caterina Tangheroni
Date Deposited: 21 Mar 2016 11:22
Last Modified: 05 Apr 2016 12:18
URI: http://eprints.imtlucca.it/id/eprint/3261

Actions (login required)

Edit Item Edit Item