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Synthesis and characterization of copolymers of methylmethacrylate and 2-hydroxyethyl methacrylate for the aqueous solubilization of Paclitaxel

Silvestri, Davide and Gagliardi, Mariacristina and Barbani, Niccoletta and Cristallini, Caterina and Giusti, Paolo Synthesis and characterization of copolymers of methylmethacrylate and 2-hydroxyethyl methacrylate for the aqueous solubilization of Paclitaxel. Drug Delivery, 16 (2). pp. 116-124. ISSN 1071-7544 (2009)

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Abstract

The aim of the present work is the modification of a hydrophobic polymeric macromolecule, polymethylmethacrylate, by introducing hydrophilic moieties of 2-hydroxyethyl methacrylate within the polymer chain. Synthesis, characterization, and drug delivery control capabilities exerted on a highly hydrophobic drug (Paclitaxel) are illustrated. In particular, the dependency of the drug delivery kinetic on the fraction of hydrophilic units inserted in the copolymer chain was studied. Results showed that it is possible to have an increase of the kinetic delivery introducing hydrophilic units. In addition, a double control, diffusive and due to the relaxation of the molecules, on drug delivery was obtained.

Item Type: Article
Identification Number: 10.1080/10717540802666980
Additional Information: Acrylic copolymer; Poly[(methyl methacrylate)-co-(2-hydroxyethyl methacrylate)]; Drug delivery polymers; Controlled drug release
Subjects: Q Science > QD Chemistry
Research Area: Computer Science and Applications
Depositing User: Caterina Tangheroni
Date Deposited: 21 Mar 2016 12:23
Last Modified: 21 Mar 2016 12:23
URI: http://eprints.imtlucca.it/id/eprint/3263

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