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Acrylic Copolymers as Candidates for Drug-Eluting Coating of Vascular Stents

Silvestri, Davide and Cristallini, Caterina and Gagliardi, Mariacristina and Barbani, Niccoletta and D'Acunto, M. and Ciardelli, G. and Giusti, Paolo Acrylic Copolymers as Candidates for Drug-Eluting Coating of Vascular Stents. Journal of Biomaterials Applications, 24 (4). pp. 353-383. ISSN 0885-3282 (2009)

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The aim of the present work is the synthesis and characterization of polymer materials showing good adhesion, drug loading, and delivery properties, for potential cardiovascular application. In particular, poly(methylmethacrylate-co-acrylic acid) copolymers are prepared in different compositions by a radical polymerization and investigated as potential materials to coat metallic stents and to carry out a local drug release. Films obtained by dissolving the copolymer in an appropriate organic solvent (also loaded with an anti-restenosis drug, such as tacrolimus) are investigated: physicochemical properties, adhesiveness to metallic stent material, and kinetics of drug release in physiological environment are studied.

Item Type: Article
Identification Number: 10.1177/0885328208095198
Subjects: Q Science > QD Chemistry
Research Area: Computer Science and Applications
Depositing User: Caterina Tangheroni
Date Deposited: 21 Mar 2016 12:25
Last Modified: 21 Mar 2016 12:25
URI: http://eprints.imtlucca.it/id/eprint/3264

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