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A 3h-flunitrazepam binding inhibitor is present in psychiatric patients’sera

Marazziti, Donatella and Pietrini, Pietro and Martini, Claudia and Giannaccini, Gino and Perugi, Giulio and Placidi, Gian Franco and Cassano, Giovanni Battista and Lucacchini, Antonio A 3h-flunitrazepam binding inhibitor is present in psychiatric patients’sera. Neuropsychobiology, 18 (2). pp. 74-76. ISSN 0302-282X (1987)

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We investigated the possible existence of endogenous compounds acting on benzodiazepine central receptors in the serum of patients with panic attacks or depression. Our results show the presence of a substance which inhibits the 3H-fiunitrazepam binding specifically in the samples taken from the patients’ groups, and which is not present in normal controls, in the range of concentrations used. This compound has a molecular weight below 1,000 daltons, is heat-stable, and resistant to proteolytic degradation. The demonstration of this inhibitor opens new perspectives in the study of the biochemistry of anxiety.

Item Type: Article
Identification Number: 10.1159/000118396
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Research Area: Computer Science and Applications
Depositing User: Caterina Tangheroni
Date Deposited: 23 Mar 2016 13:33
Last Modified: 06 Apr 2016 07:11
URI: http://eprints.imtlucca.it/id/eprint/3323

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