Pietrini, Pietro and Azari, Nina P. and Grady, Cheryl L. and Salerno, Judith A. and Gonzales-Aviles, A. and Heston, L. L. and Pettigrew, Karen D. and Horwitz, Barry and Haxby, James V. and Schapiro, Mark B. Pattern of cerebral metabolic interactions in a subject with isolated amnesia at risk for Alzheimer's disease: A longitudinal evaluation. Dementia, 4 (2). pp. 94-101. ISSN 1013-7424 (1993)
Full text not available from this repository.Abstract
A pattern of reduced cerebral metabolic rate for glucose (rCMRglc) has been shown by positron emission tomography (PET) in patients with dementia of the Alzheimer type. To verify if a similar rCMRglc pattern is present in subjects 'at risk' for Alzheimer's disease (AD), we used high-resolution PET to longitudinally study a subject with isolated memory impairment and a family history for autosomal dominant AD. Initial rCMRglc data did not reveal any consistent abnormality as compared to a group of sex- and age-matched healthy controls. However, 1 year later, a follow-up evaluation did reveal reduced parietal rCMRglc values coinciding with a worsening of cognitive impairment, which suggested that standard analyses of resting rCMRglc data may not be useful in the early diagnosis of AD. In contrast, when a previously determined discriminant function for distinguishing controls from AD patients was applied, the subject was correctly identified as an AD patient on both PET scans.
| Item Type: | Article |
|---|---|
| Identification Number: | 10.1159/000107349 |
| Subjects: | R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry |
| Research Area: | Computer Science and Applications |
| Depositing User: | Caterina Tangheroni |
| Date Deposited: | 23 Mar 2016 13:47 |
| Last Modified: | 05 Apr 2016 12:33 |
| URI: | http://eprints.imtlucca.it/id/eprint/3328 |
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