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Striatal Glucose Metabolism and Pattern of Cerebral Regional Interactions in Choreic Disorders

Pietrini, Pietro and Azari, Nina P. and Pettigrew, Karen D. and Horwitz, Barry and Kozachuk, W. and Kumar, Anand and Salerno, Judith A. and Grady, Cheryl L. and Haxby, James V. and Aronin, N. and Marshall, P. and Schapiro, Mark B. Striatal Glucose Metabolism and Pattern of Cerebral Regional Interactions in Choreic Disorders. Journal of Neuroimaging, 3 (3). pp. 151-159. ISSN 1051-2284 (1993)

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With positron emission tomography (PET), cerebral glucose metabolism was studied in 5 patients with familial inverted chorea, a progressive choreiform disease with no dementia, and in age- and sex-matched control subjects. Computed tomography scans excluded cortical or striatal atrophy. PET scans showed no group differences in striatal glucose metabolism. However, when a discriminant analysis method was applied to the PET metabolic data, a discriminant function, reflecting functional interactions involving the striatum, successfully distinguished the patients from the control subjects. These results indicate striatal involvement in the pathophysiology of familial inverted chorea, and emphasize the importance of alternative methods of analyzing regional PET data.

Item Type: Article
Identification Number: 10.1111/jon199333151
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Research Area: Computer Science and Applications
Depositing User: Caterina Tangheroni
Date Deposited: 23 Mar 2016 13:49
Last Modified: 06 Apr 2016 08:32
URI: http://eprints.imtlucca.it/id/eprint/3329

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