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The effect of brain atrophy on cerebral hypometabolism in the visual variant of Alzheimer disease

Bokde, Arun L. W. and Pietrini, Pietro and Ibáñez, Vicente and Furey, Maura L. and Alexander, Gene E. and Graff-Radford, Neill R. and Rapoport, Stanley I. and Schapiro, Mark B. and Horwitz, Barry The effect of brain atrophy on cerebral hypometabolism in the visual variant of Alzheimer disease. Archives of Neurology, 58 (3). ISSN 0003-9942 (2001)

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Background Brain glucose metabolic rates measured by positron emission tomography can be more affected by partial volume effects in Alzheimer disease (AD) than in healthy aging because of disease-associated brain atrophy. Objective To determine whether the distinct distribution of cerebral metabolic lesions in patients with the visual variant of AD (AD + VS) represents a true index of neuronal/synaptic dysfunction or is the consequence of brain atrophy. Setting Government research hospital. Design Resting cerebral metabolic rate for glucose was measured with positron emission tomography in a cross-sectional study of AD and AD + VS groups and in healthy control subjects. Segmented magnetic resonance images were used to correct for brain atrophy. Patients Patients with AD + VS had prominent visual and visuospatial symptoms. There were 15 patients with AD, 10 with AD + VS, and 37 age-matched control subjects. Main Outcome Measure Measurement of the rate of cerebral glucose metabolism. Results Before atrophy correction, the AD + VS group, compared with the control subjects, showed hypometabolism in primary and extrastriate visual areas and in parietal and superior temporal cortical areas. Compared with the AD group, the AD + VS group showed hypometabolism in visual association areas. After atrophy correction, hypometabolism remained significantly different between patients and controls and between the 2 AD groups. Conclusions The reductions in cerebral hypometabolism represent a true loss of functional activity and are not simply an artifact caused by brain atrophy. The different patterns of hypometabolism indicate the differential development of the lesions between the AD and AD + VS groups.

Item Type: Article
Identification Number: 10.1001/archneur.58.3.480
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Research Area: Computer Science and Applications
Depositing User: Ms T. Iannizzi
Date Deposited: 07 Apr 2016 10:04
Last Modified: 07 Apr 2016 10:04
URI: http://eprints.imtlucca.it/id/eprint/3398

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