Logo eprints

Regional glucose metabolic abnormalities are not the result of atrophy in Alzheimer's

Ibáñez, Vicente and Pietrini, Pietro and Alexander, Gene E. and Furey, Maura L. and Teichberg, Diane and Rajapakse, J. C. and Rapoport, Stanley I. and Schapiro, Mark B. and Horwitz, Barry Regional glucose metabolic abnormalities are not the result of atrophy in Alzheimer's. Neurology, 50 (6). pp. 1585-1593. ISSN 0028-3878 (1998)

Full text not available from this repository.


Objective To determine whether the hypometabolism observed in PET images of patients with Alzheimer's disease (AD) is due entirely to brain atrophy. Background Reduced brain glucose metabolism in AD patients measured using PET has been reported by numerous authors. Actual glucose metabolic values in AD may be reduced artificially because of brain atrophy, which accentuates the partial volume effect (PVE) on data collected by PET. Methods Using segmented MR images, we corrected regional cerebral metabolic rates for glucose for PVEs to evaluate the effect of atrophy on uncorrected values for brain metabolism in AD patients and healthy control subjects. Results Global glucose metabolism was reduced significantly before and after correction in AD patients compared with controls. Before PVE correction, glucose metabolic values in patients were lower than in control subjects in the inferior parietal, frontal, and lateral temporal cortex; in the posterior cingulate; and in the precuneus. These reductions remained significantly lower after PVE correction, although in the posterior cingulate the difference in metabolism between AD patients and control subjects lessened. Regional glucose metabolism of these areas with PVE correction was lower in moderately-severely demented patients than in mildly demented patients. Conclusion Reduced glucose metabolism measured by PET in AD is not simply an artifact due to an increase in CSF space induced by atrophy, but reflects a true metabolic reduction per gram of tissue.

Item Type: Article
Identification Number: 10.1212/WNL.50.6.1585
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Research Area: Computer Science and Applications
Depositing User: Ms T. Iannizzi
Date Deposited: 13 Apr 2016 12:27
Last Modified: 13 Apr 2016 12:27
URI: http://eprints.imtlucca.it/id/eprint/3454

Actions (login required)

Edit Item Edit Item