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Combination of event-related potentials and functional magnetic resonance imaging during single-letter reading

Casarotto, Silvia and Bianchi, Anna M. and Cerutti, Sergio and Vanello, Nicola and Ricciardi, Emiliano and Gentili, Claudio and Sani, Lorenzo and Bonino, Daniela and Guazzelli, Mario and Pietrini, Pietro and Landini, Luigi and Chiarenza, Giuseppe A. Combination of event-related potentials and functional magnetic resonance imaging during single-letter reading. In: Proceeding of the International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE, pp. 984-987. (2006)

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This work proposes a mathematical approach for combining event-related potentials (ERPs) and functional magnetic resonance images (fMRI). Data were separately recorded during the same event-related experimental design, consisting of visually presented single letters and non-alphabetic symbols, that had to be either simply observed (passive condition) or read aloud (active condition). This protocol was useful for exploring the neural correlates of reading processes. Healthy adults participated in the experiment. Averaged ERPs were decomposed by independent component analysis; low resolution electromagnetic tomography (LORETA) was applied to estimate the current density distribution maps of each independent component. fMRI images time series were analyzed by multiple linear regression. ERP-fMRI correspondence was quantified by computing the Euclidean distance between LORETA local maxima and clusters of significantly activated fMRI voxels. During reading aloud of letters, that is clearly the task most similar to natural reading conditions, significant electrical and hemodynamic response was observed in the left medial frontal gyrus (BA 6) and left middle temporal gyrus (BA 22/39) just before articulation and in the bilateral middle superior temporal gyrus (BA 22/37) during and after verbal-motor production. These results indicate that the middle-superior temporal gyrus plays a crucial and multifunctional role in grapheme-phoneme matching

Item Type: Book Section
Identification Number: 10.1109/IEMBS.2006.259272
Uncontrolled Keywords: Magnetic resonance imaging, Enterprise resource planning, Independent component analysis, Magnetic resonance, Design for experiments, Protocols, Image resolution, Tomography, Current density, Electromagnetic analysis
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Research Area: Computer Science and Applications
Depositing User: Ms T. Iannizzi
Date Deposited: 13 Sep 2016 08:14
Last Modified: 13 Sep 2016 08:14
URI: http://eprints.imtlucca.it/id/eprint/3537

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