Maffei, L. and Picano, E. and Andreassi, M. G. and Angelucci, A. and Baldacci, F. and Baroncelli, L. and Begenisic, T. and Bellinvia, P.F. and Berardi, N. and Biagi, L. and Bonaccorsi, J. and Bonanni, E. and Bonuccelli, U. and Borghini, Andrea and Braschi, C, and Broccardi, M. and Bruno, R.M. and Caleo, M. and Carlesi, C. and Carnicelli, L. and Cartoni, G. and Cecchetti, Luca and Cenni, M.C. and Ceravolo, R. and Chico, L. and Cintoli, S. and Cioni, G. and Coscia, M. and Costa, M. and D’Angelo, G. and D’Ascanio, P. and De Nes, M. and Del Turco, S. and Di Coscio, E. and Di Galante, M. and Di Lascio, N. and Faita, F. and Falorni, I. and Faraguna, U. and Fenu, A. and Fortunato, L. and Franco, R. and Gargani, L. and Gargiulo, R. and Ghiadoni, L. and Giorgi, F. S. and Iannarella, R. and Iofrida, C. and Kusmic, C. and Limongi, F. and Maestri, M. and Maffei, M. and Maggi, S. and Mainardi, M. and Mammana, L. and Marabotti, A. and Mariotti, V. and Melissari, E. and Mercuri, A. and Micera, S. and Molinaro, S. and Narducci, R. and Navarra, T. and Noale, M. and Pagni, C. and Palumbo, S. and Pasquariello, R. and Pellegrini, S. and Pietrini, Pietro and Pizzorusso, T. and Poli, A. and Pratali, L. and Retico, A. and Ricciardi, E. and Rota, G. and Sale, A. and Sbrana, S. and Scabia, G. and Scali, M. and Scelfo, D. and Sicari, R. and Siciliano, G. and Stea, F. and Taddei, S. and Tognoni, G. and Tonacci, A. and Tosetti, M. and Turchi, S. and Volpi, L. Randomized trial on the effects of a combined physical/cognitive training in aged MCI subjects: the Train the Brain study. Scientific Reports, 7. p. 39471. ISSN 2045-2322 (2017)
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Abstract
Age-related cognitive impairment and dementia are an increasing societal burden. Epidemiological studies indicate that lifestyle factors, e.g. physical, cognitive and social activities, correlate with reduced dementia risk; moreover, positive effects on cognition of physical/cognitive training have been found in cognitively unimpaired elders. Less is known about effectiveness and action mechanisms of physical/cognitive training in elders already suffering from Mild Cognitive Impairment (MCI), a population at high risk for dementia. We assessed in 113 MCI subjects aged 65–89 years, the efficacy of combined physical-cognitive training on cognitive decline, Gray Matter (GM) volume loss and Cerebral Blood Flow (CBF) in hippocampus and parahippocampal areas, and on brain-blood-oxygenation-level-dependent (BOLD) activity elicited by a cognitive task, measured by ADAS-Cog scale, Magnetic Resonance Imaging (MRI), Arterial Spin Labeling (ASL) and fMRI, respectively, before and after 7 months of training vs. usual life. Cognitive status significantly decreased in MCI-no training and significantly increased in MCI-training subjects; training increased parahippocampal CBF, but no effect on GM volume loss was evident; BOLD activity increase, indicative of neural efficiency decline, was found only in MCI-no training subjects. These results show that a non pharmacological, multicomponent intervention improves cognitive status and indicators of brain health in MCI subjects.
| Item Type: | Article |
|---|---|
| Identification Number: | https://doi.org/10.1038/srep39471 |
| Projects: | Train the Brain |
| Funders: | Fondazione Pisa |
| Uncontrolled Keywords: | Dementia; Neurological Disorders |
| Subjects: | R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry |
| Research Area: | Computer Science and Applications |
| Depositing User: | Caterina Tangheroni |
| Date Deposited: | 09 Jan 2017 09:22 |
| Last Modified: | 04 Aug 2017 10:15 |
| URI: | http://eprints.imtlucca.it/id/eprint/3618 |
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