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Statistical shape modeling of the left ventricle: myocardial infarct classification challenge

Suinesiaputra, A. and Ablin, P. and Alba, X. and Alessandrini, M. and Allen, J. and Bai, W. and Cimen, S. and Claes, P. and Cowan, B. R. and D'hooge, J. and Duchateau, N. and Ehrhardt, J. and Frangi, A. F. and Gooya, A. and Grau, V. and Lekadir, K. and Lu, A. and Mukhopadhyay, A. and Oksuz, Ilkay and Pennec, X. and Pereanez, M. and Pinto, C. and Piras, P. and Rohe, M. M. and Rueckert, D. and Sermesant, M. and Siddiqi, K. and Tabassian, M. and Teresi, L. and Tsaftaris, S. A. and Wilms, M. and Young, A. A. and Zhang, X. and Medrano-Gracia, P. Statistical shape modeling of the left ventricle: myocardial infarct classification challenge. IEEE Journal of Biomedical and Health Informatics, PP (99). p. 1. ISSN 2168-2194 (In Press) (2017)

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Abstract

Statistical shape modeling is a powerful tool for visualizing and quantifying geometric and functional patterns of the heart. After myocardial infarction (MI), the left ventricle typically remodels in response to physiological challenges. Several methods have been proposed in the literature to describe statistical shape changes. Which method best characterizes left ventricular remodeling after MI is an open research question. A better descriptor of remodeling is expected to provide a more accurate evaluation of disease status in MI patients. We therefore designed a challenge to test shape characterization in MI given a set of three-dimensional left ventricular surface points. The training set comprised 100 MI patients, and 100 asymptomatic volunteers (AV). The challenge was initiated in 2015 at the Statistical Atlases and Computational Models of the Heart workshop, in conjunction with the MICCAI conference. The training set with labels was provided to participants, who were asked to submit the likelihood of MI from a different (validation) set of 200 cases (100 AV and 100 MI). Sensitivity, specificity, accuracy and area under the receiver operating characteristic curve were used as the outcome measures. The goals of this challenge were to (1) establish a common dataset for evaluating statistical shape modeling algorithms in MI, and (2) test whether statistical shape modeling provides additional information characterizing MI patients over standard clinical measures. Eleven groups with a wide variety of classification and feature extraction approaches participated in this challenge. All methods achieved excellent classification results with accuracy ranges from 0.83 to 0.98. The areas under the receiver operating characteristic curves were all above 0.90. Four methods showed significantly higher performance than standard clinical measures. The dataset and software for evaluation are available from the Cardiac Atlas Project website1.

Item Type: Article
Identification Number: 10.1109/JBHI.2017.2652449
Uncontrolled Keywords: Biomedical imaging;Biomedical measurement;Diseases;Heart;Informatics;Shape;Training;Cardiac modeling;classification;myocardial infarct;statistical shape analysis
Subjects: Q Science > QA Mathematics > QA75 Electronic computers. Computer science
R Medicine > RZ Other systems of medicine
T Technology > T Technology (General)
Research Area: Computer Science and Applications
Depositing User: Caterina Tangheroni
Date Deposited: 01 Feb 2017 08:49
Last Modified: 01 Feb 2017 08:49
URI: http://eprints.imtlucca.it/id/eprint/3652

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