Logo eprints

Memory and anatomical change in severe non missile traumatic brain injury: ∼1 vs. ∼8 years follow-up

Tomaiuolo, Francesco and Bivona, Umberto and Lerch, Jason P. and Paola, Margherita Di and Carlesimo, Giovanni A. and Ciurli, Paola and Matteis, Mariella and Cecchetti, Luca and Forcina, Antonio and Silvestro, Daniela and Azicnuda, Eva and Sabatini, Umberto and Giacomo, Dina Di and Caltagirone, Carlo and Petrides, Michael and Formisano, Rita Memory and anatomical change in severe non missile traumatic brain injury: ∼1 vs. ∼8 years follow-up. Brain Research Bulletin, 87 (4–5). 373 - 382. ISSN 0361-9230 (2012)

Full text not available from this repository.


In previous studies, we investigated a group of subjects who had suffered from a severe non missile traumatic brain injury (nmTBI) without macroscopic focal lesions and we found brain atrophy involving the hippocampus, fornix, corpus callosum, optic chiasm, and optic radiations. Memory test scores correlated mainly with fornix volumes 37,38. In the present study, we re-examined 11 of these nmTBI subjects approximately 8 yr later. High-spatial resolution \{T1\} weighted magnetic resonance images of the brain (1 mm3) and standardised memory tests were performed once more in order to compare brain morphology and memory performance originally assessed 3–13 months after head injury (first study) and after 8–10 yr (present study). An overall improvement of memory test performance was demonstrated in the latest assessment, indicating that cognitive recovery in severe nmTBI subjects had not been completed within 3–13 months post-injury. It is notable that the volumes of the fornix and the hippocampus were reduced significantly from normal controls, but these volumes do not differ appreciatively between nmTBI subjects at first (after ∼1 yr) and at second (after ∼8 yr) scans. On the contrary, a clear reduction in the volume of the corpus callosus can be observed after ∼1 yr and a further significant reduction is evident after ∼8 yr, indicating that the neural degeneration in severe nmTBI continues long after the head trauma and relates to specific structures and not to the overall brain.

Item Type: Article
Identification Number: 10.1016/j.brainresbull.2012.01.008
Uncontrolled Keywords: Craniocerebral trauma; nmTBI; CHI; Coma; Neuroanatomy; Memory
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Research Area: Computer Science and Applications
Depositing User: Caterina Tangheroni
Date Deposited: 04 Aug 2017 10:27
Last Modified: 04 Aug 2017 10:27
URI: http://eprints.imtlucca.it/id/eprint/3747

Actions (login required)

Edit Item Edit Item