Tsaftaris, Sotirios A. and Tang, Richard and Zhou, Xiangzhi and Li, Debiao and Dharmakumar, Rohan An area-based imaging biomarker for the characterization of coronary artery stenosis with blood oxygen-sensitive MRI. In: 19th meeting of the international society for magnetic resonance in medicine, 7-13 May 2011, Montreal, Quebec, Canada (Unpublished) (2011)Full text not available from this repository.
BOLD MRI may be used for detecting myocardial oxygenation changes secondary to coronary artery stenosis (1-3). Under pharmacological stress, the myocardial bed supplied by the stenotic coronary artery appears hypointense relative to healthy regions in BOLD images. Manual windowing (to visualize signal changes) and segmentation according to the American Heart Association’s (AHA) recommendation are often used to characterize the BOLD effect. However, current approaches for analyzing BOLD changes are suboptimal for detecting critical stenosis (reduction in perfusion reserve below 2:1). The purpose of this study is to test the hypothesis that, ARREAS (Area-based biomaRker for chaRactErizing coronAry Stenosis), an area-based statistical approach relying on the differences between rest and stress images, can characterize BOLD changes in end-systole and end-diastole with exquisite sensitivity and specificity. This hypothesis was tested in a canine model.
|Item Type:||Conference or Workshop Item (Poster)|
|Subjects:||R Medicine > RC Internal medicine
T Technology > TK Electrical engineering. Electronics Nuclear engineering
|Research Area:||Computer Science and Applications|
|Depositing User:||Users 35 not found.|
|Date Deposited:||09 Sep 2011 12:28|
|Last Modified:||05 Mar 2013 15:30|
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