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Robust Model Predictive Control for optimal continuous drug administration

Sopasakis, Pantelis and Patrinos, Panagiotis and Sarimveis, Haralambos Robust Model Predictive Control for optimal continuous drug administration. Computer Methods and Programs in Biomedicine, 116 (3). pp. 193-204. ISSN 0169-2607 (2014)

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In this paper the Model Predictive Control (MPC) technology is used for tackling the optimal drug administration problem. The important advantage of MPC compared to other control technologies is that it explicitly takes into account the constraints of the system. In particular, for drug treatments of living organisms, MPC can guarantee satisfaction of the minimum toxic concentration (MTC) constraints. A whole-body physiologically-based pharmacokinetic (PBPK) model serves as the dynamic prediction model of the system after it is formulated as a discrete-time state-space model. Only plasma measurements are assumed to be measured online. The rest of the states (drug concentrations in other organs and tissues) are estimated in real time by designing an artificial observer. The complete system (observer and MPC controller) is able to drive the drug concentration to the desired levels at the organs of interest, while satisfying the imposed constraints, even in the presence of modeling errors, disturbances and noise. A case study on a PBPK model with 7 compartments, constraints on 5 tissues and a variable drug concentration set-point illustrates the efficiency of the methodology in drug dosing control applications. The proposed methodology is also tested in an uncertain setting and proves successful in presence of modelling errors and inaccurate measurements.

Item Type: Article
Identification Number: 10.1016/j.cmpb.2014.06.003
Uncontrolled Keywords: Drug Administration Control; Drug Dosing; PBPK Modelling; Model Predictive Control
Subjects: Q Science > QA Mathematics > QA75 Electronic computers. Computer science
T Technology > TJ Mechanical engineering and machinery
Research Area: Computer Science and Applications
Depositing User: Ms T. Iannizzi
Date Deposited: 19 Jun 2014 08:09
Last Modified: 02 Sep 2014 09:28
URI: http://eprints.imtlucca.it/id/eprint/2208

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