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Bioresorbable microspheres as devices for the controlled release of paclitaxel

Guerra, Giulio D. and Cristallini, Caterina and Barbani, Niccoletta and Gagliardi, Mariacristina Bioresorbable microspheres as devices for the controlled release of paclitaxel. International Journal of Biology and Biomedical Engineering, 5 (3). pp. 121-128. ISSN 1998-4510 (2011)

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The release of the anti-cancer drug paclitaxel (PTX) from microspheres of both a bioresorbable poly(ε-caprolactoneoxyethylene- ε-caprolactone) tri-block copolymer and of polyurethanes containing either copolymers with the same composition and different molecular weights or poly(ε-caprolactone) diol as soft segments was studied. The microspheres, both loaded and not with PTX, were prepared by emulsion-evaporation technique, then characterized by SEM and DSC. The quantities of PTX released were measured by HPLC. The results showed slow and very regular releases, which fit very well the Peppas equation, Mt/M? = k · tn, where Mt is the amount of solute released at the time t, M? is the amount of drug released at the plateau condition, k represents the Peppas kinetic constant and n the diffusion order. Most n values are consistent with non-Fickian release mechanisms, with the exceptions of two less hydrophilic polyurethanes.

Item Type: Article
Uncontrolled Keywords: Controlled release, microspheres, paclitaxel, poly(ester-ether-ester)s, polyurethanes.
Subjects: Q Science > QD Chemistry
Research Area: Computer Science and Applications
Depositing User: Caterina Tangheroni
Date Deposited: 21 Mar 2016 09:59
Last Modified: 06 Apr 2016 07:42
URI: http://eprints.imtlucca.it/id/eprint/3256

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