Sopasakis, Pantelis and Sarimveis, Haralambos An integer programming approach for optimal drug dose computation. Computer Methods and Programs in Biomedicine, 108 (3). pp. 1022-1035. ISSN 0169-2607 (2012)
Full text not available from this repository.Abstract
In this paper, we study the problem of determining the optimal drug administration strategy when only a finite number of different dosages are available, a lower bound is posed on the time intervals between two consecutive doses, and drug concentrations should not exceed the toxic concentration levels. The presence of only binary variables leads to the adoption of an integer programming (IP) scheme for the formulation and solution of the drug dose optimal control problem. The proposed method is extended to account for the stochastic formulation of the optimal control problem, so that it can be used in practical applications where large populations of patients are to be treated. A Finite Impulse Response (FIR) model derived from experimental pharmacokinetic data is employed to correlate the administered drug dose with the concentration–time profiles of the drug in the compartments (organs) of the body.
| Item Type: | Article |
|---|---|
| Identification Number: | 10.1016/j.cmpb.2012.06.008 |
| Uncontrolled Keywords: | Optimal drug dosing; FIR model; Pharmacokinetics; Integer programming |
| Subjects: | Q Science > QA Mathematics > QA75 Electronic computers. Computer science R Medicine > RM Therapeutics. Pharmacology |
| Research Area: | Computer Science and Applications |
| Depositing User: | Users 44 not found. |
| Date Deposited: | 24 Jan 2013 09:27 |
| Last Modified: | 12 Mar 2013 14:57 |
| URI: | http://eprints.imtlucca.it/id/eprint/1463 |
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