Laurino, Marco and Stano, Maurizio and Betta, Monica and Pannocchia, Gabriele and Landi, Alberto Combining pharmacological therapy and vaccination in Chronic Myeloid Leukemia via model predictive control. In: 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), July 3-7, 2013, Osaka, Japan pp. 3925-3928. ISSN 1558-4615. ISBN 978-1-4577-0216-7. (In Press) (2013)
Full text not available from this repository.Abstract
This paper describes a simulation study which aims at optimizing the therapy for the control of Chronic Myeloid Leukemia according to the following objectives: the reduction of the administered drug and vaccine amounts, the establishment of a auto-immune response and the long-term control of disease without reducing the effective of therapy with respect to the full treatment. A therapy optimization method is developed defining and solving a Model Predictive Control algorithm, preceded by an accurate Initial Guess search based on Monte-Carlo like approach. Simulation results show that the suggested procedure achieves the proposed goals.
| Item Type: | Conference or Workshop Item (Paper) |
|---|---|
| Identification Number: | 10.1109/EMBC.2013.6610403 |
| Subjects: | Q Science > QH Natural history > QH301 Biology R Medicine > R Medicine (General) |
| Research Area: | Computer Science and Applications |
| Depositing User: | Caterina Tangheroni |
| Date Deposited: | 04 Sep 2017 13:51 |
| Last Modified: | 04 Sep 2017 13:51 |
| URI: | http://eprints.imtlucca.it/id/eprint/3773 |
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