Logo eprints

Controlled drug administration by a fractional PID

Sopasakis, Pantelis and Sarimveis, Haralambos Controlled drug administration by a fractional PID. In: Proceedings of the 19th IFAC World Congress. IFAC, pp. 8421-8426. ISBN 978-3-902823-62-5 (2014)

PDF (Pre-print version)
Download (203kB) | Preview


Amiodarone is an antiarrhythmic drug that exhibits highly complex and non-exponential dynamics whose controlled administration has important implications for its clinical use especially for long-term therapies. Its pharmacokinetics has been accurately modelled using a fractional-order compartmental model. In this paper we design a fractional-order PID controller and we evaluate its dynamical characteristics in terms of the stability margins of the closed loop and the ability of the controlled system to attenuate various sources of noise and uncertainty.

Item Type: Book Section
Identification Number: 10.3182/20140824-6-ZA-1003.00740
Additional Information: 19th IFAC World Congress, August 24-29, 2014, Cape Town, South Africa
Uncontrolled Keywords: Biomedical control; Biomedical systems; Pharmacokinetics and drug delivery; Control of physiological and clinical variables; Physiological model; Fractional control
Subjects: Q Science > QA Mathematics > QA75 Electronic computers. Computer science
R Medicine > RM Therapeutics. Pharmacology
Research Area: Computer Science and Applications
Depositing User: Ms T. Iannizzi
Date Deposited: 21 Oct 2014 13:19
Last Modified: 22 Oct 2014 08:17
URI: http://eprints.imtlucca.it/id/eprint/2327

Actions (login required)

Edit Item Edit Item