Sopasakis, Pantelis and Sarimveis, Haralambos Controlled drug administration by a fractional PID. In: Proceedings of the 19th IFAC World Congress. IFAC, pp. 8421-8426. ISBN 978-3-902823-62-5 (2014)
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Abstract
Amiodarone is an antiarrhythmic drug that exhibits highly complex and non-exponential dynamics whose controlled administration has important implications for its clinical use especially for long-term therapies. Its pharmacokinetics has been accurately modelled using a fractional-order compartmental model. In this paper we design a fractional-order PID controller and we evaluate its dynamical characteristics in terms of the stability margins of the closed loop and the ability of the controlled system to attenuate various sources of noise and uncertainty.
| Item Type: | Book Section |
|---|---|
| Identification Number: | 10.3182/20140824-6-ZA-1003.00740 |
| Additional Information: | 19th IFAC World Congress, August 24-29, 2014, Cape Town, South Africa |
| Uncontrolled Keywords: | Biomedical control; Biomedical systems; Pharmacokinetics and drug delivery; Control of physiological and clinical variables; Physiological model; Fractional control |
| Subjects: | Q Science > QA Mathematics > QA75 Electronic computers. Computer science R Medicine > RM Therapeutics. Pharmacology |
| Research Area: | Computer Science and Applications |
| Depositing User: | Ms T. Iannizzi |
| Date Deposited: | 21 Oct 2014 13:19 |
| Last Modified: | 22 Oct 2014 08:17 |
| URI: | http://eprints.imtlucca.it/id/eprint/2327 |
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